Kai-Ping Chang
Chang Gung Memorial Hospital & Chang Gung University, Taiwan
Title: Discovery of salivary biomarkers for detecting oral squamous cell carcinoma by systemic approaches
Biography
Biography: Kai-Ping Chang
Abstract
In Taiwan, oral squamous cell carcinoma (OSCC), representing 90% of oral cavity cancers, is rated as the sixth highest cause of cancer deaths in Taiwan, and accounts for 3% of all newly diagnosed cancer cases in which 27% of male OSCC are between 30-50 years old (the 2009 Cancer Registry of Department of Health of Taiwan). Th e overall 5-year survival rate and morbidity for patients with OSCC has not been improved over the past two decades due to lacking suitable markers for early detection. Th e incidence of oral cancer continuously increases and the social and economic impacts on the aff ected populations are huge. In the past few years, head and neck research group collaborated by Chang Gung Memorial Hospital and Chang Gung University has used various basic research platforms including the genomic approach and proteomic approach attempting to search and identify the novel biomarkers and discussing their related mechanisms and pathogenesis for oral cavity squamous cell carcinoma. In this presentation, I’ll share our experience to apply the two basic research platforms, including a multiplexed bead-based platform to simultaneously detect auto-antibodies and comparative secretome profi ling for primary cell cultures derived from OSCC and adjacent noncancerous epithelium, to discover the potential salivary marker for the detection of OSCC. In these works, we have already demonstrated that THBS2 and a combined panel of salivary auto-antibodies could be eff actively useful for OSCC detection.