Sibel Akyol and Murat Hanci
Istanbul University, Turkey
Title: The relationship between NKG2D-ligand and anesthesia before and after digital subtraction angiography
Biography
Biography: Sibel Akyol and Murat Hanci
Abstract
Aim: Th is study aims to provide the infl uence of anesthesia on the expression of natural killer cells and major histo-compatibility complex (MHC) molecules patients who had cerebral digital subtraction angiography (DSA) for either the diagnosis or treatment of intracranial vascular pathologies. Material & Methods: Forty-one male patients who admitted for cerebral DSA were included in this study. Patients were divided into two groups: Group I (n=7) included patients who did not receive anesthesia and group II (n=34) received anesthesia. For the molecules, a venous blood samples from every patient was collected before and aft er cerebral DSA. Results: In the group I, NK cells, NKG2D, MICA/MICB, CD3 and CD8 cytokines were increased signifi cantly aft er the DSA but CD16+56+ and MHC-class I showed no statistical signifi cant diff erence. In the group, NK cells, CD16+56+ and MICA/ MICB levels did not show signifi cant diff erence. On the other hand NKG2D, MHC-class I, CD8+ and CD3+ levels increased signifi cantly aft er the DSA. Comparing the group I and II aft er the DSA showed no signifi cant diff erence regarding CD16+56+ and NKG2D. NK (CD56+), MICA/MICB decreased and MHC-class I, CD8+, and CD3+ levels increased signifi cantly in the group II. Conclusion: Anesthesia combined with surgical stress DSA causes some alterations in the immune status of the patients. More data will lead us to give appropriate agents to the patients in order to strengthen the immune status during the preoperative period for decreasing the morbidity and/or mortality rate.